Preliminarey single dose toxicological investigation of livina capsule in mice model
Soumendra Darbar, Shyamaprasad Chattopadhyay
Background: Toxicology is the important part of pharmacology which deals with the undesirable effect of phytocompounds on living organisms previous to the use as drug or chemical in clinical use. Acute toxicity studies are conducted to determine the short-term adverse effects of a drug when administered in a single dose, or in two or three times per day. It is used as a part of occupational health environmental impact assessments and batch release testing. Aims and Objectives: The basic objective of the study is to evaluate the toxic effect of Livina capsule in mice. Study Methods: The study was conducted according to the guidelines of OECD. Swiss albino mice weighing between 20 and 35 gm were selected for the study. Results: Livina capsule in single oral dose (2000mg/kg) supplemented to all mice. The parameters like general appearance, behavior, body weight, mortality and necropsy were studied. No changes in general appearance and mortality was observed. Conclusion: Livina capsule was found to be safe at dose of 2000mg/kg.
Soumendra Darbar, Shyamaprasad Chattopadhyay. Preliminarey single dose toxicological investigation of livina capsule in mice model. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 5, Issue 3, 2020, Pages 26-28