Fast disintegrating tablets are novel drug delivery type of tablets that dissipate in saliva within a few seconds without the need of water. The object of the present investigation was to design and evaluate oral disintegrating tablet (ODT) of Ibuprofen, a non-steroidal anti-inflammatory drug used for the treatment of arthritis with a view to ameliorating its oral bioavailability. The focus of the study was to develop ODT of ibuprofen using super disintegrating agents for ease of administration and its physiochemical characterization. All the formulations F1-F5 were prepared by using direct compression method. Different parameters like pre-compression parameters like angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio and post compression parameters like friability, hardness, thickness, drug content were tested and the disintegration time was in the range of 45 to 55 seconds an in-vitro dispersion time was found to be 22 to 55 seconds. Where F3 formulation offered the relatively rapid release of ibuprofen when compared with other formulations.