Medication error can lead to significant aftermath in a patient care system which can be numerous like increased adverse drug event rates, unanticipated economic burden, increased risk of mortality and morbidity. The clinical care world is blooming than ever before with a rapid and strategic planning of development of newer methods of health care management for a better patient care. The aim of the study was to identify and evaluate the failures of medication errors and its severity analysis in a Tertiary Care Hospital of Ranchi in India. The data for the present study was collected from medication error form, reported and updated daily by the authorised people, mainly clinical pharmacists. Data were collected in data collection form and raw data were transferred to electronic database for further detail analysis. From this study, it is evident that prescription error and medication errors can be reduced considerably by executing an audit and intervention of prescriptions and conducting clinical audits in a regular interval.