Multiple emulsions are novel carrier system which are multiphase, complex and polydispersed in nature where both w/o and o/w emulsion exists simultaneously in a single system. Multiple emulsions are also called as emulsions of emulsions, liquid membrane system or double emulsion. It is important to prevent the problem of oral drug delivery system and they are stabilized by using of combination of both hydrophilic and lipophilic surfactant. It finds wide range of applications in targeted drug delivery, vaccine adjutants, delivery of proteins and peptides, taste masking, treatment of drug overdose, controlled or sustained drug delivery, bioavailability enhancement, enzyme immobilization and as intermediate step in microencapsulation process. Also in cosmetics, these systems can prevent degradation of an active ingredient and release it at a controlled rate. Progression in techniques for preparation, stabilization and rheological characterization of multiple emulsions, it will be able to provide a new carrier system for drugs, cosmetics and pharmaceutical agents. The aim of this article was to provide a detailed review of types, formulation approaches, preparation methods, evaluation parameters and applications of multiple emulsions.
Anagha Ajagekar, Firoj Tamboli, Harinath More, Namdeo Jadhav, Vishal H Thorat, Manish Wani. Development of pharmaceutical multiple emulsion: An overview. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 6, Issue 2, 2021, Pages 26-31