The suspending properties of Azanza garckeana pectin in magnesium carbonate suspension
Oraeluno JN, Obasi JC, Bamigbola EA, Joseph BA
Many natural agents have been employed as suspending agents in pharmaceutical suspension formulations. The need to expand the base of natural suspending agents used in the pharmaceutical industries necessitated this study. The purpose of this work was to produce cheap, available and effective natural excipient to be used as an alternative for the formulation of pharmaceutical suspensions. The suspending properties of Azanza garckeana pectin (Malvaceae) was studied in comparison with tragacanth gum and acacia gum at concentrations of 1 to 4%w/v in magnesium carbonate suspension. pH, sedimentation volume, viscosity, redispersibility and flow rate of suspensions were used as parameters for evaluation. It was observed that their suspending ability was in the order of Azanza garckeana > tragacanth > acacia. From this study, the higher the concentration of these suspending agents, the higher the PH, sedimentation volume, redispersibility number, viscosity and reverse for the flow rate. The results suggest that Azanza garckeana pectin has best suspending properties amongst the investigated natural polymers at all concentration used and thus has good characteristic as a novel suspending agent in pharmaceutical suspensions.