Medicinal plants are worth to nature. The bioactive compounds present in medicinal plants have various pharmaceutical importance. Helicteres isora commonly known as the Indian screw tree (Marorphali), has been reviewed for its phytochemical and pharmacological significance. The fruit, leaf, bark, root, and seed mainly contains carbohydrates, saponin, tannin, proteins, steroids, anthraquinon glycosides, cardiac glycosides, phenolic compounds, terpenoides, alkaloid salts, free alkaloids, flavonoid glucuronides, α-tocopherol, reduced glutathione, and sapogenin. The plant has therapeutical importance and mainly shows antidiabetic, antioxidant, anticancer, antinociceptive, antimicrobial, antispasmodic, anti-inflammatory activities. The plant has been used in the traditional system of medicine to treat stomach-related disorders like stomachache, diarrhea, wormicide, and snakebite.