International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 6, Issue 3 (2021)

Enhancement of dissolution rate of phenytoin by solid dispersion technology using hydrophilic polymers


Shaikh Shahnoor, Savitri Pol, Bhandare Pooja, Gharge Varsha

Objective: Enhancement of dissolution rate of Phenytoin by solid dispersion technology using hydrophilic polymers and solid state characterization & dissolution behavior Methods: Formulation parameters evaluated by the solvent evaporation method at drug: different polymer ratios Results: The results showed that PEG 6000-based solid dispersion exhibited significantly higher phenytoin dissolution. Phenytoin has high melting point, which is indicative of strong crystal lattice energy. All solid dispersions of phenytoin prepared with PEG 6000 and poloxamer 407 polymers showed enhanced drug solubility over the pure phenytoin (0.11) mg/ml in distilled water and (0.23)mg/ml in phosphate buffer 6.8. The in vitro release studies were carried out for the phenytoin solid dispersions prepared by melting method. The dissolution rate of pure phonation was very poor and during 120 min a maximum about 28.55% of the drug was released. Conclusion: The formulation of solid dispersion of a drug with hydrophilic crriers is a potential approach used to improve the solubility and dissolution rate of practically water insoluble or less soluble drugs
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