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VOL. 6, ISSUE 4 (2021)
Acute toxicity evaluation of Elva in crude and processed forms in Wistar rats
Authors
Sadique Husain, Abudul Wadud, Nasreen Jahan, Humaira Bano
Abstract
Background and objective: Herbal medicines are preferred mainly because of their safety, but some important drugs obtained from natural sources are highly toxic in nature whereas some are moderately harmful. However, toxic and harmful drugs are used after subjecting them to some processes of detoxification either to remove the element of harmful effects completely or at least to minimize it. Elva, the test drug; is said to be harmful for the various organs of the body, therefore, the drug are used after making it Mudabbar (Detoxified). The test drugs were named as EGM (Elva ghair mudabbar) and EM (Elva mudabbar) were subjected to acute toxicity study according to OECD Guidelines 423. The study was carried out in non-pregnant female Wistar rats of 150-200 gm. The animals were randomly selected and kept in standard laboratory conditions. The dosing for Elva was started from 2000 mg/kg dissolving in Carboxymethyl Cellulose (CMC) in three animals per group. The animals were randomly selected and kept in standard laboratory conditions. Features of acute toxicity included general observation, haematology, biochemistry and histopathology. No significant changes except increased HDL-C in EGM were recorded in EM. However, the harmful effects may be a precursor of toxicity if the drugs are used in overdose or for prolonged periods.
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Pages:21-27
How to cite this article:
Sadique Husain, Abudul Wadud, Nasreen Jahan, Humaira Bano "Acute toxicity evaluation of Elva in crude and processed forms in Wistar rats ". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 6, Issue 4, 2021, Pages 21-27
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