M Sakthivel, B Prathap, K Pargunan, S Nandhini, S Karthikeyan, A Ajitha
Topical drug delivery system is defined as the application of pharmaceutical dosage form to the skin for direct treatment of cutaneous disorder. The skin present a first line of defence against a wide range of bacterial invaders. Topical route offer several advantages including the avoidance of systemic toxicity and side effect. Topical dosage form have been generally classified as liquid, semisolid, etc.The main purpose of the study is document the requirements are involved in manufacturing of semisolid dosage form. The guidelines are also include classification, API, instrumentation and evaluation of semisolid dosage form. The studies about the effet of manufacturing process and formulation excipients of semisolid have contributed significantly toward their characterization. The semisolid dosage form are contain one or more active ingredients dissolved or uniformly dispersed in a suitable excipients such as emulsifier, antioxidant, preservative, penetration enhancer, gelling agent, chelating agent, emulgent, humectant, stabilizer. Semisolid can adhere to application surface for long term before washed off. So, this property help prolong drug delivery at application site. The semisolid are greasy in nature are made up of oleagenous bases. The another one is non greasy in natureare made up of water washable bases. The most conventional and probably well-known semisolid dosage form are cream, ointment, paste, gels, etc. The review is concern with all detail infomation regrading approaches to formulation and evaluation of semisolid dosage form.
M Sakthivel, B Prathap, K Pargunan, S Nandhini, S Karthikeyan, A Ajitha. Review about semisolid dosage form. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 6, Issue 5, 2021, Pages 31-36