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VOL. 6, ISSUE 6 (2021)
Evaluation of nephroprotective activity of methanolic extract of santalum album leaves
Authors
Nikitha K, Sreekanth
Abstract
The present study designed to evaluate the protective effect of leaves extract (methanol) of Santalum album Linn. plant against cisplatin-induced nephropathy and gentamycin induced nephropathy in rats. Cisplatin and gentamycin administered rats (toxic control group) had encountered acute kidney dysfunction as evidenced by elevation in serum urea and creatinine, decreased urine output and body weight with multiple histological damages. Treatment with the methanol extract of Santalum album leaves at the dose level of 400 mg/kg b.w. for 14 days and 21 respectively (SAME400 group) significantly lowered the serum level of creatinine and urea, decreased urine creatinine and albumin with a significant weight gain, and increased urine output when compared with the toxic group. The histological damages in the Santalum album -treated group were minimal in contrast to the toxic rats. The statistical significance of the nephroprotective activity of Santalum album - treated group and the polyherbal drug cystone (standard group)-treated group (both the groups were compared against toxic control) were found to gain same level of significance (P<0.001) against the toxic group.
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Pages:19-27
How to cite this article:
Nikitha K, Sreekanth "Evaluation of nephroprotective activity of methanolic extract of santalum album leaves ". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 6, Issue 6, 2021, Pages 19-27
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