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VOL. 6, ISSUE 6 (2021)
Formulation and evaluation of curcumin embedded casein nanoparticle by micellar technique
Authors
Tanuja A J, Jayanthi C, Hanumanthachar Joshi
Abstract
The aim of this work is to develop and evaluated curcumin embedded casein Nanoparticle. The incorporation of curcumin inside a nanoglobules to improve curcumin stability and permeability. A nanoparticle was prepared by micells technique. using an casein, tween80 and NAOH. Evaluation of the nanoparticle included analysis of particlesize, Zeta potential, free drug content, Drug loading, % encapsulation, Invitro release studies, and stability study. Particle size range of 385.9-90.96. and 617.7 - 116.6 of BY and CY formulation respectively. Zeta potential was and it was found to be -2.6 mV and -2.9 mV of BY and CY formulation respectively. The percent of drug loading range 0.08 to 4.0 mg. The percentage entrapment efficiency was found to be 2.6% to 46.5%. Curcumin in a nanoparticle was more stable than free curcumin. The invitro release kinetic of curcumin shows maximum release 96.05 ±0.98 in CY formulation and changed zero order to a Higuchi release profile. Overall, the developed nanoparticle system improved curcumin permeability but also protected the curcumin from chemical degradation.
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Pages:28-35
How to cite this article:
Tanuja A J, Jayanthi C, Hanumanthachar Joshi "Formulation and evaluation of curcumin embedded casein nanoparticle by micellar technique ". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 6, Issue 6, 2021, Pages 28-35
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