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VOL. 7, ISSUE 1 (2022)
Echinometra mathaei cream activity against blood profile of male white rats induced by grade II burns
Authors
Hardiyono, Angelica Kresnamurti, Rayanti Fitri Lestari
Abstract
Administration of Echinometra mathaei cream has been shown to heal second-degree burns in previous studies. This study aims to determine the effect of the concentration of the ethanolic extract of Echinometra mathaei in the form of cream on changes in the blood profile of rats induced by second-degree burns, compared with sulfadiazine cream. This research is a true experimental design with post test control group design. The animals used were 30 male wistar rats which were divided into 6 groups including normal rats, negative control group, positive control given sulfadiazine cream, and 3 groups of Echinometra mathaei cream with concentrations of 1%, 3%, and 5%. Burn induction was given with a 20 mm diameter hot plate for 15 seconds, at a temperature of 1000C. Blood sampling through the heart was carried out on the 7th day after administration of burn cream. Data were analyzed using ANOVA and followed by a post hoc test with LSD. The results showed that the administration of Echinometra mathaei extract cream did not show significant differences in the count of leukocytes, erythrocytes, hematocrit, platelets, and hemoglobin (p<0.05). The data showed an improvement in the levels of leukocytes, erythrocytes and hemoglobin in the group of rats given Echinometra mathaei extract cream and silver sulfadiazine, compared to the negative control group. The conclusion of this study is that the administration of Echinometra mathaei extract cream for 7 days did not give a significant difference to the negative and positive controls on the blood profile data of male white rats induced by second degree burns.
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Pages:1-4
How to cite this article:
Hardiyono, Angelica Kresnamurti, Rayanti Fitri Lestari "Echinometra mathaei cream activity against blood profile of male white rats induced by grade II burns ". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 7, Issue 1, 2022, Pages 1-4
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