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VOL. 7, ISSUE 1 (2022)
Design and development of guar gum based curcumin nanoparticles for dissolution enhancement
Authors
Tanuja A J, Jayanthi C
Abstract
Nanoparticles of curcumin and guar gum were prepared by emulsion - evaporation & cross linking technique. Encapsulation efficiency of the prepared curcumin loaded nanoparticles was found to be in the range of 74% to 90%. The mean particle size of the nanoparticle formulation was found to be in the range of 225-296nm. The encapsulated curcumin was in an amorphous form as detected by differential scanning colorimetry rather than in a crystalline form & the curcumin molecules have interacted with the guar gum molecules in the nanoparticulate system. FTIR measurements provided some information about the nature of interactions inside the nanoparticles. Pure curcumin spectrum (FigI) exhibited the characteristic peak in the intensities of O-H stretch at 3510cm-1, the C=O stretching frequencies of ester linkage at 1627cm-1, the C-C stretch ( aromatic ring) at 1599cm-1 (CCC) stretch, (CCH) in plane bending (C-O-C) of aromatic and inter ring chain of pure curcumin at 1427cm-1, (CCC) stretch and (CCH) in plane bending of the aromatic "keto" part at 1278cm-1 & 1153cm-1. As these characteristic peaks appeared in the loaded & unloaded nanoparticle formulation with minor shifts in the peaks and confirmed the loading of curcumin into guar gum in the prepared nanoparticulate system. The guar gum molecules offers a flexible & easily controllable process for modulating delivery characteristics which are important in controlling the drug release rate.
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Pages:11-20
How to cite this article:
Tanuja A J, Jayanthi C "Design and development of guar gum based curcumin nanoparticles for dissolution enhancement ". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 7, Issue 1, 2022, Pages 11-20
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