NLCs (nanostructured lipid carriers) are novel medicinal formulations that combine physiological and biocompatible lipids with surfactants and co-surfactants. Over time, NLC has evolved into a second-generation lipid nanocarrier and a potential alternative to first-generation nanoparticles. According to this review research, the structure, content, numerous formulation techniques, and description of NLCs are all factors for establishing a reliable drug delivery system. NLCs have a lot of promise in the pharmaceutical and cosmetics sectors because of their multiple advantages such skin hydration, occlusion, improved bioavailability, and skin targeting. This essay aims to arouse interest in the most cutting-edge NLC by demonstrating how they can aid existing drug delivery methods. The simplicity of production, biocompatibility, scale-up practicality, non-toxicity, improved drug loading, and stability of NLC make it a potential drug delivery technology.