Pharmacological evaluation of Bauhinia variegate root for analgesic and anti- inflammatory activity
Nikitha K, Mohammed Swalih K
The research was designed to evaluate the analgesic and anti-inflammatory activity of aqueous extract of Bauhinia variegateroots using different animal models. Analgesic activity was assessed by using various two animal models namely, Writing Test using acetic acid in mice and Hot Plate Method. The degree of analgesic activity was determined by the number of writhing and was recorded for each animal by Writing Test using acetic acid in mice model and the delay in reaction time for of each animal when place in hot plate maintained at 55±0.10c is recorded in Hot Plate Method. Anti-inflammatory activity was evaluated using Formalin induced paw edema model, Croton oil ear edema in rats, turpentine oil granuloma model. Aqueous extract of Bauhinia variegateroot produced significant analgesic activity in both Hot plate and acetic acid induced writhing models in mice. In hot plate method percentage increase in reaction time was evaluated where as in acetic acid induced writhing model percentage decrease in writhing was determined. Evaluation of anti-inflammatory activity was done by Formalin induced paw edema model, Croton oil ear edema model and turpentine oil induced granuloma model respectively. In Formalin induced paw edema model mean change in paw volume and percentage protection were calculated. In croton oil ear edema model the difference between untreated ear and treated ear were determined which indicated degree of inflammatory edema. In turpentine oil granuloma model the change in paw volume and percentage inhibition of inflammation were calculated. The study revealed that the Bauhinia variegateroots possess a significant analgesic and anti-inflammatory activity.
Nikitha K, Mohammed Swalih K. Pharmacological evaluation of Bauhinia variegate root for analgesic and anti- inflammatory activity. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 7, Issue 3, 2022, Pages 16-25