International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 7, Issue 3 (2022)

Evaluation of diuretic activity of seed and hydro-alcoholic extract of Blepharis maderaspatensis ex roth heyne– A folklore plant


Devang Y Joshi, Mukesh Kumar B Nariya, Rajesh Barvaliya

Introduction: Blepharis maderaspatensis is used as a diuretic medicine as a folklore plant. Aim & Objective: The aim of the research study is to evaluate the single dose diuretic activity of seed powder and hydro-alcoholic extract of the Utigan. Materials & Methods: The wistar albino rats were divided into 6 different groups containing 6 animals per group. The normal control group, ref. std. group (10 mg/kg, po), Utigan powder at low and high dose (67.5mg/kg and 135mg/kg) and Utigan extract at low and high dose (100mg/kg and 200mg/kg po) respectively. 1 hour after the administration of drug animals were kept in metabolic cages and urine of 6hrs and 24 were collected and volume, and electrolytes were evaluated. Result & Observation: Utigan powder at high dose and extract at low dose significantly increase urine volume at 24 hrs. Utigan powder at low and high dose significantly increase the excretion of Na+ and K+ through urine and have high diuretic index. In the conclusion it is revealed that Utigan powder at both doses shows diuretic activity and extract have less diuretic activity when compared with normal control group. Conclusion: This study shows the diuretic activity of B. maderaspatensis possibly mediated through loop diuretic effects, which rationalizes its medicinal use as a diuretic.
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How to cite this article:
Devang Y Joshi, Mukesh Kumar B Nariya, Rajesh Barvaliya. Evaluation of diuretic activity of seed and hydro-alcoholic extract of Blepharis maderaspatensis ex roth heyne– A folklore plant. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 7, Issue 3, 2022, Pages 11-15
International Journal of Research in Pharmacy and Pharmaceutical Sciences International Journal of Research in Pharmacy and Pharmaceutical Sciences