There has been high in severity of infection causes fungas in present time. Antifungal require prolonged treatment some of the systemic fungal infection may be life threatening. Antifungal drug have positive effect as well as negative effect including on heart and liver Failure They have need to testing every 4 to 6 weets For kidney, liver & heart damage depending on antifungal pills Sometime infection reverse after treatment. For Mucosal & systemic yeast infection Floconazole is widelyused, drug is widely used. For the nail infection, terbinafine drug is used. For the oral thrush nystatin drug is used & For the vaginal thrush Floconazole is used. (3)