Curcuma longa, phoenix dactylifera, Beta vulgaris and Zimgiber zerumber possesses numerous medicinal values which include their antidiabetic, anti-inflammatory, anticancer, antimicrobial as well asi-obesity. Hexanolic extracts of the plants were subjected to quantitative phytochemical screening and tested for antimicrobial activities (Sparfloxacin, Ciprofloxacin and fluconazole) were used as standard drugs. Twenty (20) bioactive secondary metabolites were quantified and detected in the samples. Phytate recorded the highest concentrations (43.536, 41.836, 42.28 and 45.231 µg/mol) while sapogenin recorded the lowest concentrations (0.873, 0.786, 0.236 and 0.153 µg/mol) for Curcuma longa, phoenix dactylifera, Beta vulgaris and Zimgiber zerumber respectively. The pathogens used in this study were Pseudomonas aeruginosa, Staphylococcus aereus, Salmonella entrerica, Citrobacter murliniae, Bacillus licheniformis, Micrococcus roseus, Bacillus subtilis, Salmonella typhi, Protus Mirabilis, Candida albicans, Candida krusei, Candida tropicalis, Aspergillus niger and Aspergillus fumigatus. All pathogens were confirmed sensitive to the plant extracts. This work has shown scientific evidences on the usefulness of the plants investigated and their uses in trado-medicines to ascertain its claims by ethno-medical practitioners as well as their ability to serve as antibiotic drug candidates.