The propensity toward novel drug delivery technologies over the past few decades has significantly boosted efforts to guarantee efficacy, safety, and patient acceptance. The development of novel drug delivery systems for already existing medications is becoming more popular as the research and development of new chemical agents is a difficult, expensive, and time-consuming process. Orally disintegrating films are a popular drug delivery method in both children and geriatrics. These rapid disintegrating films are better than fast disintegrating tablets because the latter have choking and friability issues. Compared to traditional fast-dissolving tablets, this drug delivery system offers many advantages since it can be used for patients with dysphasia and schizophrenia and because it can be taken without water. One of the most significant oral dose forms for pharmaceuticals is orally disintegrating films (ODFs). It has been observed, nonetheless, that the hygroscopicity of ODFs compromises both their mechanical strength and stability. To investigate the impact of the water content on the mechanical properties of the films and the time it takes for them to disintegrate, we created model ODFs with three different water contents by storing them under various relative humidity conditions. The most used technique for evaluating the mechanical properties of films intended for oral disintegration is the tensile test. The folding endurance (FE) test, which is another accessible test, is more suited for determining the actual strength during manufacture and dosage. However, the FE test is performed manually, and the FE number it generates has not been adequately analysed as an index. These studies aimed to establish an automatic method for determining the FE number and to compare the resulting FE numbers with the tensile properties. Due to the best level of patient compliance, particularly in geriatric and paediatric patients, oral disintegrating systems have established a niche among oral drug delivery systems.