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VOL. 8, ISSUE 3 (2023)
Development and characterization of mouth dissolving films of montelukast sodium
Authors
Mohammad Zishan Ibrahim, Jameel Ahmad, Mohd. Ameen Mahmood, Shaikh Abid Shabbir, Sayyed Javvad Ali
Abstract
The aim of this investigation was to develop
rapid dissolving oral films containing Montelukast Sodium, with the goal of
achieving a high onset of action to enhance the management of allergic
rhinitis. The solvent-casting method is used for preparation of mouth disolving
film of Montelukast Sodium, there were six batches were prepared of mouth
dissolving films, by using polymer HPMC K4M, HPMC K100, and HPMC K15M as
film-forming ingredient. Various parameters were evaluated for thickness,
weight variations, folding endurance, surface pH, disintegration, drug content,
and in-vitro drug release, etc. Among all the formulated batches, Batch
F4 exhibited exceptional characteristics, boasting a minimal disintegration
time of only 17 seconds. Moreover, it demonstrated the highest drug release,
with an impressive 96.32% of the drug being released within just 30 minutes,
surpassing the performance of the other formulate d batches. Thus, F4 was selected as the optimized
formulation. Analysis through FTIR indicated that there were no significant
interactions between the drug and the polymers used in the optimized
formulation. In conclusion, the development of fast dissolving film
formulations of Montelukast represents a promising approach for the treatment
of allergic rhinitis. These films offer the advantage of rapid dissolution,
leading to enhanced therapeutic efficacy.
Pages:32-37
How to cite this article:
Mohammad Zishan Ibrahim, Jameel Ahmad, Mohd. Ameen Mahmood, Shaikh Abid Shabbir, Sayyed Javvad Ali "Development and characterization of mouth dissolving films of montelukast sodium". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 8, Issue 3, 2023, Pages 32-37
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