ARCHIVES
VOL. 8, ISSUE 4 (2023)
Development and evaluation of 90% alpha lipoic acid coated with suitable polymers
Authors
Shiva Prasad, Venkatesh, P K Kulkarni, Nagendra R, Hanumanthachar Joshi
Abstract
LA-based nutraceuticals are in high demand right now, despite having a wide range of benefits, α-lipoic acid (ALA) is administered orally, which has pharmacokinetic restrictions that lower its therapeutic efficacy. ALA is well absorbed from the intestine however; ALA polymerises in acidic pH in the stomach. Hence the current study envisages coat particles or granules of ALA with, suitable polymers such as PVP/HPMC: these coats separate the drug from external gastric fluid it protect from polymerization and improve bioavailability. The present research started with the Preformulation studies on the active ingredient physical properties, compatibility of API with excipients by physical observation and FT-IR studies, DSC studies. The results showed that there was no interaction. The prepared granules were evaluated for Micromeritic properties. The formulation studies led to three formulas that presented a good flowability, considered adequate for the direct compression process. The percentage drug content was found in the range of 89 % to 91% for all the formulations, which was within the I.P acceptable limits. The solubility profiles of the formulations and the pure medication were compared in vitro. Formulations showed a higher rate of solubility than pure drug. The product subjected for 3 months accelerated stability study suggest that the drug is stable for a period of 3 months (stability study period) at accelerated condition, hence the study concludes that Alpha Lipoic acid can be formulated into a granulated ALA with a greater stability. LA coated with HPMC as granules were successfully produced using coating technology. HPMC has the ability to improve powder adhesion to the granule surface and promote film formation. With optimized temperature we could achieve a smoother surface and better coating uniformity for granules.
Pages:10-16
How to cite this article:
Shiva Prasad, Venkatesh, P K Kulkarni, Nagendra R, Hanumanthachar Joshi "Development and evaluation of 90% alpha lipoic acid coated with suitable polymers". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 8, Issue 4, 2023, Pages 10-16
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