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VOL. 8, ISSUE 4 (2023)
Formulation and evaluation of floating drug delivery system of fosinopril
Authors
Preethu M N, Nagendra R, Venkatesh, K Hanumanthachar Joshi
Abstract
The present research work
is an attempt to develop and evaluate floating drug delivery system of
Fosinopril in order to improve drug bioavailability. A floating drug delivery
system helps toimprove the buoyancy property of the drug over gastric fluids so
it maintains the longer duration of action this also helps in minimizing the
dosing frequency. Floating tablets of Fosinopril were prepared with solid
dispersion by physical mixture by usingPEG4000.Tablets are prepared with the
direct compression method by using HPMC K4M, HPMC K15M and Carbopol as polymer.
Fosinopril floating tablets were prepared utilising both separate and combined
polymers. Different ratios of the polymers HPMC, Carbopol 940, and guar gum
were utilised. Five formulations in total (AF1–AF5) were prepared. All the
formulations were subjected for the flow properties—bulk density, tap density,
and angle of repose- the results were found to bewithin the acceptable range.
The direct compression method was used to prepare the flotation tablets of
Fosinopril. The direct compression approach is quick, easy, and
labor-intensive. These formulations (AF1-AF5) were examined for a number of
tests, including dissolving studies, homogeneity of content, friability, and
weight fluctuation. In vivo studies to evaluate the performance and
application of floating systems, and applications of these systems.
Thesesystems are useful to several problems encountered during the development
of apharmaceutical dosage form. The formulations (AF1) made with HPMC and (AF2)
made with Carbopol 940 both demonstrated good floating times of 8 hours. With a
floating time of 8 hours and a drug release of roughly 98.4% at the end of 24
hours, the formulation (AF1) containing hydroxypropyl methylcellulose was
discovered to be the optimum formulation.
Pages:20-25
How to cite this article:
Preethu M N, Nagendra R, Venkatesh, K Hanumanthachar Joshi "Formulation and evaluation of floating drug delivery system of fosinopril". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 8, Issue 4, 2023, Pages 20-25
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