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VOL. 8, ISSUE 4 (2023)
Method development and validation of amlodipine besylate in API and pharmaceutical dosage form by UV spectroscopy
Authors
Banothu Bhadru, Narender Boggula, Tadikonda Rama Rao, Yelimeti Santhosha, Fathima Zainab
Abstract
An analytical method was developed for the determination of amlodipine
besylate in API and tablet dosage form, and UV-Spectrophotometric was employed
to develop a sensitive and accurate method. In order to determine the amount of
amlodipine besylate in bulk and its formulation, the current study intended to
develop a straight forward, accurate, quick, and affordable
UV-Spectrophotometric assay method. The chosen water to use as a solvent while
preparing the stock solution. Amlodipine besylate was detected at a λmax of
245nm. Amlodipine used in this approach had a regression coefficient (r2)
of 0.9993 and exhibited linearity at concentrations of 2, 4, 6, 8 and 10μg/ml.
With the formulation of amlodipine besylate API, the percent drug content was
found to be 100.15. Recovery studies, where recoveries were almost 100% and
%RSD is low, demonstrated the accuracy and precision of the method.
Pages:26-29
How to cite this article:
Banothu Bhadru, Narender Boggula, Tadikonda Rama Rao, Yelimeti Santhosha, Fathima Zainab "Method development and validation of amlodipine besylate in API and pharmaceutical dosage form by UV spectroscopy". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 8, Issue 4, 2023, Pages 26-29
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