ARCHIVES
VOL. 9, ISSUE 1 (2024)
In vitro quality evaluation of brands of ciprofloxacin tablets marketed in Edo State, Nigeria
Authors
Adeniyi Akee M A, Nnorodim J I, Ahmad A A, Obarisiagbon J
Abstract
Due to the rise in generic medicine products
from various sources. People and prescribers now have to choose from a variety
of items that appear to be pharmaceutically equivalent and this put regulating
authorities under pressure, resulting in an influx of counterfeits and poor
products. Ciprofloxacin is a second generation fluoroquinolones used in the
case of typhoid fever, gonorrhea and urinary tract infection. The aim of this
research was to evaluate the quality control parameters of ten brands of
tablets ciprofloxacin hydrochloride marketed by drugstores around Edo State in
Nigeria. Identification, hardness, disintegration, uniformity of weight,
dissolution, friability and assay are the factors determined. The United State
and the British Pharmacopoeia were used as standards for the evaluation of
samples. Results obtained showed tablets weight ranging 0.634 ± 1.249 ％, hardness from 7.4 ± 0.44 to 14.99 ± 0.03 kg/cm2,
friability values of less than (˃) 1 % except CP-9 Brand, disintegration period
of 1.43 ± 0.02 to 22.62 ± 0.19 min, assay of 91.3 to 110 %, and the brands
released 70 % of their drug content within 45 min. The results indicated that
overall quality of all tested ciprofloxacin hydrochloride tablets brands was
satisfactory as they met the requirements of the official and unofficial quality
control test.
Pages:6-11
How to cite this article:
Adeniyi Akee M A, Nnorodim J I, Ahmad A A, Obarisiagbon J "<i>In vitro </i>quality evaluation of brands of ciprofloxacin tablets marketed in Edo State, Nigeria". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 1, 2024, Pages 6-11
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