In cases where pharmacological therapy may have serious side effects, such as in the case of gynecological disorders like amenorrhea, dysmenorrhea, premenstrual syndrome, pelvic floor dysfunction, or polycystic ovary syndrome (PCOS), many women choose to use hormonal replacement therapy to treat these symptoms instead of pharmaceutical therapy. Here, we examined the management of gynecological problems, which are frequently utilized for the aforementioned indications, with an emphasis on clinical data and a safe profile. We pointed out that information is available regarding the usage of different pharmacological classes, including biguanides, aromatase inhibitors, and antiandrogens, to treat the side effects of oral contraceptives. In addition, hormone replacement therapy (HRT) for gynecological and menopausal problems uses progestin and estradiol.