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VOL. 9, ISSUE 1 (2024)
Nanosponge based hydrogel for enhancement of permeation and retention of anti-fungal drugs: A review
Authors
Yash Bhausaheb Kadam, Indrajeet D Gonjari, Sakshi D Wankhade, Divya B Jagdale, Pranita K More
Abstract
The creation of a targeted medicine delivery
system is the result of recent advancements in nanotechnology. However, a
specialised drug delivery system is needed to successfully target a molecule to
a specific place utilising a drug delivery system. Because they can accommodate
both hydrophilic and hydrophobic drugs, the development of nanosponge has
become a crucial step in solving some issues such as drug toxicity, low
bioavailability, and predictable drug release. Because of their porous nature,
nanosponges have the unusual capacity to capture drug moieties and provide a
benefit of desire release. Nanosponges are microscopic sponges that can move
throughout the body to target areas and adhere to surfaces to release drugs in
a predictable and regulated way. Crosslinking polymers produces nanosponges,
which are three-dimensional drug delivery systems at the nanoscale. One of
their advantages is that they can accommodate a large variety of different
sized medications. There are numerous sizes and shapes for nanosponges. Their
differentiation stems from the kind of polymer employed, the research
methodology employed, and the potential medication composition. Because they
can administer drugs with targeted distribution and a regulated release
pattern, nanosponges are superior to alternative delivery technologies.
Different polymers with varying concentrations, such as carbopol 940,
hydroxypropyl methyl cellulose, methyl cellulose, pectin, and pluronic P407,
were used to manufacture the gel. Physical characteristics such as colour,
syneresis, spreadability, pH, drug concentration, and rheological properties
were assessed for ten distinct formulas.
Pages:12-16
How to cite this article:
Yash Bhausaheb Kadam, Indrajeet D Gonjari, Sakshi D Wankhade, Divya B Jagdale, Pranita K More "Nanosponge based hydrogel for enhancement of permeation and retention of anti-fungal drugs: A review". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 1, 2024, Pages 12-16
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