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VOL. 9, ISSUE 1 (2024)
Nanostructured lipid carriers: An emerging approach for nose to brain delivery of drugs in the treatment of various CNS disorders
Authors
Divya B Jagdale, Indrajeet D Gonjari, Yash B Kadam, Pranita K More, Akshay B Jadhav
Abstract
The administration of medications for
illnesses affecting the central nervous system (CNS) is difficult since these
medications must pass through the blood-brain barrier (BBB) to reach the brain.
The use of the intranasal route to deliver medications straight from the nose
to the brain has shown encouraging results among the many approaches that have
been researched to get around this problem. Furthermore, by enhancing the
bioavailability and site-specific delivery, the encapsulation of the
medications in lipid-based nanocarriers, such as nanostructured lipid carriers
(NLCs), can enhance nose-to-brain transport. The most recent in vivo research using
lipid-based nanocarriers (NLCs) for nose-to-brain transfer is reviewed in this
study. Drawing from the body of research published in the last 24 months, we
offer an understanding of the various pathways that medications may take to
enter the brain following intranasal delivery. The findings of research on
pharmacokinetics and pharmacodynamics are presented, together with a careful
examination of the variations in the nasal cavity anatomy among the many animal
species employed in in vivo investigations. Drugs tend to be more effectively targeted to the
brain when taken via the intranasal route in conjunction with NLCs, despite the
fact that the precise mechanism of drug transport from the nasal passages to
the brain is still unclear and its efficacy in humans is uncertain. These
systems are anticipated to be approved by regulatory bodies in the upcoming
years since it has been demonstrated that they are more efficacious for
nose-to-brain transport than other routes or preparations with non-encapsulated
medicines.
Pages:25-32
How to cite this article:
Divya B Jagdale, Indrajeet D Gonjari, Yash B Kadam, Pranita K More, Akshay B Jadhav "Nanostructured lipid carriers: An emerging approach for nose to brain delivery of drugs in the treatment of various CNS disorders". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 1, 2024, Pages 25-32
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