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VOL. 9, ISSUE 1 (2024)
Microspheres: A review on novel approach for enhancement of aqueous solubility of BCS class II drugs
Authors
Pranita K More, Indrajeet D Gonjari, Akshay B Jadhav, Divya B Jagdale, Yash B Kadam
Abstract
Oral modified-release multiple-unit dosage
forms have always been more effective therapeutic alternative to conventional
or immediate release single-unit dosage forms. In terms of the ultimate dosage
form, hard gelatin capsules are typically filled with multiparticulates that
have been formed into microspheres. Microspheres gained a lot of interest for
their ability to target drugs in addition to their sustained release.
Multiparticulate drug delivery systems or microspheres, are intended to
deliver medications at a particular rate to a specific site. Microspheres are
free-flowing powders with particle sizes ranging from 1 to 1000µm that are
composed of synthetic polymers or biodegradable proteins. advantages of using
microspheres in industries including bone tissue production, medication
delivery, and pollutant absorption and desorption via regeneration. The study
demonstrates the microsphere parameter design and measurement process. There
are several different types of microspheres, including bioadhesive, polymeric,
magnetic, floating, and radioactive microspheres. Microspheres have potential
applications in multiple domains, including gene delivery, ocular drug
delivery, target drug delivery, oral drug administration, and cosmetics, among
others mentioned in the paper. Achieving the best therapeutic efficacy requires
delivering the drug to the target tissue at the proper concentration in a
specific duration of time, with the least amount of toxicity and side effects
possible. There are various methods for continuously managing the delivery of
the drug to the intended site. Using microspheres as drug carriers is one such
approach. The current aim of this review is to investigate the formulation,
assessment, and characterization processes as well as other aspects of the
microparticulate drug delivery system in a constant, controlled manner.
Pages:47-55
How to cite this article:
Pranita K More, Indrajeet D Gonjari, Akshay B Jadhav, Divya B Jagdale, Yash B Kadam "Microspheres: A review on novel approach for enhancement of aqueous solubility of BCS class II drugs". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 1, 2024, Pages 47-55
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