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VOL. 9, ISSUE 1 (2024)
Phytosomes: Promising approach for the delivery of phytoconstituents
Authors
Akanksha B Shinde, Yogeshkumar N Gavhane, Anjali V Sapate, Rutuja A Nalawade, Pranita K More
Abstract
Herbal drugs are a great option for treating a
wide range of illnesses in the modern world. Yet, their therapeutic application
may be severely limited due to their limited selectivity and bioavailability.
This means that the phytosome technology is a state-of-the-art approach meant
to tackle the problem of limited bioavailability. The term "phyto"
refer to plants, "some" refer to individual cells. This innovative
formulation creates lipid-compatible molecular complexes with improved
absorption and bioavailability by combining phospholipids with a standardised
plant extract. The phosphatidylcholine moiety functions as the bifunctional.
Phosphatidylcholine is an essential part of phytosomes, because it gives
effective drug loading capacity. Compound's head, the choline moiety which is
inherently hydrophilic. Compound's tail, phosphatidyl moiety is naturally
lipophilic. When hydrophilic phytoconstituents bind to the choline portion of
the molecule, the lipid-soluble phosphatidyl component of the
phosphatidylcholine molecule envelops the choline-bound complex. This leads to
the production of a phyto-phospholipid complex with higher lipid solubility.
Phytosomes offer several benefits, such as higher bioavailability, better
nutritional efficacy and better entrapment efficiency. This review is made to
give comprehensive insights about the phytosomes, its chemical composition,
mechanism of phytosome formation, advantages, method of preparation &
characterization.
Pages:61-66
How to cite this article:
Akanksha B Shinde, Yogeshkumar N Gavhane, Anjali V Sapate, Rutuja A Nalawade, Pranita K More "Phytosomes: Promising approach for the delivery of phytoconstituents". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 1, 2024, Pages 61-66
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