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VOL. 9, ISSUE 1 (2024)
Atorvastatin and ezetimibe protect against hypercholesterolemia: An overview
Authors
Madhuri Lode, Rama Rao Tadikonda, Narender Boggula
Abstract
High blood levels of triglycerides (fats) and cholesterol are treated
with a combination of atorvastatin and ezetimibe in conjunction with a balanced
diet. This medication may aid in the prevention of illnesses (such as heart
attacks and strokes) brought on by blocked blood arteries. HMG-CoA reductase
inhibitors, or statins, include atorvastatin and ezetimibe, which both limit
the absorption of cholesterol. Both the amount of cholesterol your body
produces and absorbs from food will be decreased by these medications. This
article explains the various analytical techniques that have been developed and
validated in accordance with ICH guidelines for the determination of
atorvastatin and ezetimibe. This review describes the drugs like atorvastatin
and ezetimibe description, pharmacodynamics, pharmacokinetics, and toxicity. These
techniques include UV-Spectrophotometry, Ultra Performance Liquid
Chromatography (UPLC), Mass spectrometric, Liquid chromatography-Mass
spectroscopy (LC-MS). It is crucial to analyze the drug content and purity
percentage in bulk and pharmaceutical formulations for quality control
purposes.
Pages:67-71
How to cite this article:
Madhuri Lode, Rama Rao Tadikonda, Narender Boggula "Atorvastatin and ezetimibe protect against hypercholesterolemia: An overview". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 1, 2024, Pages 67-71
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