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VOL. 9, ISSUE 2 (2024)
Co-crystallization: Technique for solubility enhancement - A review
Authors
Smita D Londhe, Avinash H Hosmani, Amrapali B Jadhav, Darshna Salam, Snehal Name
Abstract
In recent years, there has been a lot of
interest in the design and synthesis of pharmacological co-crystals. A great
chance exists for the production of novel pharmaceutical products with enhanced
pharmacological and physical characteristics, such as bioavailability,
stability, hydroscopicity, solubility, and dissolution rates, through
co-crystallization of medicinal components. When developing a therapeutic
formulation, the physicochemical qualities of active medicinal ingredients,
such as their solubility and flow characteristics, are vital. The compound's
physical form and formulation may have an impact on the drug's
biopharmaceutical characteristics. While keeping the drug molecule's inherent
action, the physical characteristics of the active pharmaceutical ingredients
can be changed by the use of crystal engineering. The benefits of co-crystals
over salts, solvates (hydrates), solid dispersions, and polymorphs are
discussed in this article along with their formation mechanism, preparation
techniques, and use in altering the physicochemical properties of active pharmaceutical
ingredients. An attempt is made to incorporate documented works on co-crystals,
which contribute to a deeper understanding of the idea.
Pages:13-18
How to cite this article:
Smita D Londhe, Avinash H Hosmani, Amrapali B Jadhav, Darshna Salam, Snehal Name "Co-crystallization: Technique for solubility enhancement - A review". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 2, 2024, Pages 13-18
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