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VOL. 9, ISSUE 2 (2024)
Glycerosomes: A comprehensive review on noval liposomal drug delivery system for efficient delivery of therapeutics
Authors
Anjali V Sapate, Yogesh N Gavhane, Akanksha B Shinde, Darshana B Salam, Snehal S Name
Abstract
In recent years the topical drug delivery
system has gained more interest as compared to oral and parenteral drug
delivery. But only a small number of drug molecules can be delivered this way
because of the skin’s outermost layer barrier function. Encapsulating the
medication within glycerosomes is therefore one way to potentially solve this
problem. Glycerosomes are new vesicular drug delivery vehicles that can be
applied topically or systemically. Glycerosomes can be primarily prepared from
water, phospholipids and high concentration of glycerol (from 10 to 30 %) these
components are safe and suitable for use in topical preparation. Glycerosomes
are improved liposomes, designed for transdermal and topical medication
administration. Despite the fact that liposomes are a flexible drug delivery
method, there are certain issues still need to be resolved, primarily those
associated with entrapment, penetration, fluidity and stability. Compared to
traditional liposomes, these drug delivery methods exhibit enhanced stability,
fluidity, entrapment and penetration. In glycerosomes penetration and stability
dramatically increases by using phospholipids and when glycerol concentration
is raised up to 10, 20, or 30. Glycerosomes have the ability to encapsulate
both hydrophilic and lipophilic drug to prevent from degradation. Glycerosomes
carriers are currently the most attractive research topic for scientists. This
review article provides brief overview on advantages and disadvantages, methods
of preparation, characterization and evaluation, applications of glycerosomes
in various fields based on previously published research papers.
Pages:19-27
How to cite this article:
Anjali V Sapate, Yogesh N Gavhane, Akanksha B Shinde, Darshana B Salam, Snehal S Name "Glycerosomes: A comprehensive review on noval liposomal drug delivery system for efficient delivery of therapeutics". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 2, 2024, Pages 19-27
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