ARCHIVES
VOL. 9, ISSUE 3 (2024)
Design, development and evaluation of herbal extract loaded nanogel of wrightia tinctoria for diabetic wounds
Authors
S Arunkumar, K Balachandhar
Abstract
The project aimed to formulate and evaluate a nanogel loaded with wrightia
tinctoria (w. tinctoria) leaves extract for its potential diabetic wound
healing activity. W. tinctoria, commonly known as the Sweet Indrajao or Pala
Indigo Plant, is known for its medicinal properties, including wound healing.
Nanogels have gained attention in recent years as a promising drug delivery
system due to their small size, high stability, and ability to encapsulate
various bioactive compounds. The project began with the extraction of wrightia
tinctoria leaf extract using a suitable solvent. The extract was then loaded
into a nanogel formulation using a specific technique. The formulation process
involved optimization of various parameters such as polymer concentration,
surfactant type, and stirring speed to achieve a stable and effective nanogel.
The formulated nanogel was subjected to various characterization tests to
assess its physical and chemical properties, such as particle size, zeta
potential, drug loading efficiency, and in vitro release profile. These
tests confirmed the successful encapsulation of wrightia tinctoria leaf extract
within the nanogel and its controlled release behaviour. The findings of this
project suggest that wrightia tinctoria leaf extract-loaded nanogel holds great
promise as a potential therapeutic option for diabetic wound healing
applications. The nanogel formulation can provide controlled and sustained
release of active compounds, improving the efficacy and duration of the wound
healing process.
Pages:24-29
How to cite this article:
S Arunkumar, K Balachandhar "Design, development and evaluation of herbal extract loaded nanogel of <i>wrightia tinctoria </i>for diabetic wounds". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 3, 2024, Pages 24-29
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