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VOL. 9, ISSUE 3 (2024)
Enhancement of the solubility and bioavailability of Ursodeoxycholic acid through a self nano emulsifying drug delivery system
Authors
M L Indhumathi, S Mahalakshmi, Barish
Abstract
Ursodeoxycholic acid (UDCA) is a bile acid that presents high
lipophilicity which is used in the treatment of cholestatic liver diseases and
belongs to class Ⅱ Biopharmaceutical Classification System (BCS), which
exhibits low water solubility and high intestinal permeability which leads to
poor oral absorption. The goal of this study was to develop a Self Nano
Emulsifying Drug Delivery System (SNEDDS) of UDCA to improve its solubility and
bioavailability. The excipients were selected based on the maximum solubility
of UDCA in various oil, surfactant & cosurfactant and observed by UV
spectrophotometer. Different combinations of oils, surfactant, and cosurfactant
was optimised by 32 factorial design to prepare UDCA-SNEDDS
formulation. Cinnamon oil, span 80, Ethanol were used as an oil, surfactant and
co-surfactant respectively. The selected formulation F5 were analysed for Size,
Self emulsification time, Drug content, Scanning Electron Microscopy (SEM) and In-vitro
dissolution study. The UDCA-SNEDDS formulation exhibited Size 277.8nm and good
PDI with proper Stability. The invitro drug release in phosphate buffer PH
6.8 from selected UDCA-SNEDDS F5 was about 63% after 8 hours. These
outcomes imply that UDCA-SNEDDS may serve as an effective means of enhancing
UDCA’s liver activity by improving the solubility and bioavailability of UDCA.
Pages:35-40
How to cite this article:
M L Indhumathi, S Mahalakshmi, Barish "Enhancement of the solubility and bioavailability of Ursodeoxycholic acid through a self nano emulsifying drug delivery system". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 3, 2024, Pages 35-40
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