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VOL. 9, ISSUE 3 (2024)
Formulation and evaluation of desonide ethosomal gel
Authors
K Seenivasan, R Priyadharshini, Barish, S Mahalakshmi
Abstract
Development of novel drug delivery carriers
are a necessity to deliver the drugs to target site at a faster rate to
overcome the drawbacks of multi-dose therapy, Thereby it reduced the frequency
of dosing, increased the bioavailability of drug and increase patient
compliance and improve their safety. For drug delivery via dermal and
transdermal routes ethosomes have emerged as a non-invasive mean, ethosome is
novel lipid carrier, showing enhanced skin delivery. The ethosomal system is
composed of phospholipid, ethanol and water. The size of ethosomes varies from
few nanometres to micrometres depending on method of preparation and
application of techniques like, sonication. Several studies investigated the
effect of ethanol on physicochemical characteristics of the ethosomal vesicles.
The aim of our investigation was to evaluate the transdermal potential of novel
vesicular carrier. ethosomes containing topical Corticosteroid DESONIDE,
anti-inflammatory and antipruritic agents were successfully entrapped into the
ethosomal vesicles. Apart from ethanol, propylene glycol was also used as
permeation enhancer which would improve the solubility and partitioning of drug
across the membrane. this formulation produced excellent drug release ensured
that this was effective formulation for the treatment of various Skin
infections. Including Psoriasis and Atopic Dermatitis.
Pages:49-53
How to cite this article:
K Seenivasan, R Priyadharshini, Barish, S Mahalakshmi "Formulation and evaluation of desonide ethosomal gel". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 3, 2024, Pages 49-53
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