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VOL. 9, ISSUE 3 (2024)
Comparative study of in vivo effects of Glipizide and Metformin-HCl on plasma concentration of Aminophylline in healthy rats
Authors
K Ravi Shankar, M Trinadharao, K Vijay Kumar, MSN Murthy, Pydiraju Kondrapu
Abstract
The Drug Drug interactions will alter the mechanism and therapeutic
efficacy of one drug either by showing Antagonistic and Synergistic Actions. In
this we explain a relation between Asthma and Diabetes. Simultaneous
Administration of Aminophylline with Metformin HCl does not alter the plasma
drug Concentration of Aminophylline. But Administration with Glipizide shows
significant changes in the plasma drug concentration of Aminophylline. This may
be due to higher Affinity of Glipizide for the plasma protein. So Competitive
inhibition of the binding to the plasma protein on the mixed condition can lead
to hazardous consequences i,e. Competitive inhibition of the binding to the
plasma protein by Glipizide Increase the plasma concentration of Aminophylline.
Such Interactions of drugs can Effect the Binding of Plasma proteins &
subsequently change in plasma concentration of drugs. The plasma concentration
of free drug in plasma &tissues after redistribution may change in
Pharmacokinetic properties of drugs.
Pages:95-98
How to cite this article:
K Ravi Shankar, M Trinadharao, K Vijay Kumar, MSN Murthy, Pydiraju Kondrapu "Comparative study of <i>in vivo</i> effects of Glipizide and Metformin-HCl on plasma concentration of Aminophylline in healthy rats". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 3, 2024, Pages 95-98
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