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VOL. 9, ISSUE 3 (2024)
Enhancing transdermal drug delivery for Rheumatoid arthritis: A review on penetration enhancers
Authors
R Navyasree, Dr. Vikram T, Gururaj S Kulkarni, Padmaa M Paarakh, Muthukumar
Abstract
One common inflammatory arthritis that affects extra-articular tissues
such as the skin, lungs, and heart is called rheumatoid arthritis (RA). NSAIDs
have a number of disadvantages despite being used for therapy on a regular
basis. Transdermal medication administration has become a viable substitute,
providing benefits over oral therapy such avoiding the gastrointestinal system
and improving patient adherence. The stratum corneum (SC), the skin's outermost
layer, presents a substantial obstacle to drug absorption, constantly.
Penetration enhancers, which can be synthetic or natural, are used to get
around this. By lessening the SC's barrier qualities, these substances aid
medication penetration of the skin. Sesame oil, turpentine oil, tulsi oil,
terpenes, isopropyl myristate (IPM), oleic acid, Transcutol (TR), sucrose fatty
acid esters, 1-menthol, and ethanol are just a few of the penetration enhancers
that are examined in this review with an emphasis on their potential to improve
the efficacy of topical formulations for RA.
Pages:88-94
How to cite this article:
R Navyasree, Dr. Vikram T, Gururaj S Kulkarni, Padmaa M Paarakh, Muthukumar "Enhancing transdermal drug delivery for Rheumatoid arthritis: A review on penetration enhancers". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 3, 2024, Pages 88-94
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