Aim: It is a research work of preparing ODTs of pantoprazole as a model PPI using direct compression technique and sublimation employing various super disintegrants.

Method: ODT formulations were developed according to the direct compression and sublimation method, and the pre-compression parameters such as bulk density, tapped density, the angle of repose, Carr’s Index, and Hausner’s ratio were evaluated. Characterizations of the formulated ODTs involved colour, shape, hardness and friability, tablet thickness and weight variation, drug content homogeneity, in-vitro dispersion time and in-vitro dissolution rate. FTIR was used to investigate drug-excipient interaction and stability test were done on the selected formulations through short term accelerated stability studies.

Result: In the ODTs prepared the disintegration time and the release time were also very less as desired for better patient compliance.