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VOL. 9, ISSUE 4 (2024)
Design and evaluation of pharmacosomes loaded with telmisartan
Authors
Nachikethana C R, Venkatesh, Parthasarathi K Kulkarni, Hanumanthachar Joshi
Abstract
The research focused on creating pharmacosomes with telmisartan to
enhance its solubility, bioavailability, and reduce toxicity. Using soya
phosphatidylcholine in varying ratios, the complex was prepared via solvent
evaporation. The optimized formulation (F1, 1:1 ratio) achieved a drug
concentration of 96.83% w/w. Characterization through X-ray powder diffraction
confirmed complex formation, while scanning electron microscopy showed
disc-shaped particles. In in vitro dissolution studies, F1 released 94.69% of the drug over ten hours,
compared to 60.42% for pure telmisartan. These findings suggest that the phospholipid
complex significantly improves telmisartan's solubility and therapeutic
potential.
Pages:14-21
How to cite this article:
Nachikethana C R, Venkatesh, Parthasarathi K Kulkarni, Hanumanthachar Joshi "Design and evaluation of pharmacosomes loaded with telmisartan". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 4, 2024, Pages 14-21
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