ARCHIVES
VOL. 9, ISSUE 4 (2024)
Investigation of antineoplastic activities using Panc-1 and Hepg-2 cell lines on Tamarindus indica bark
Authors
Renukaradhya M, A M Krupanidhi, Prakash Dabadi
Abstract
Cancer is a growing health problem around the world and is the second
leading cause of death after heart disease. According to a recent report by the
International Agency for Research on Cancer (IARC), in 2008 there were 12.7
million new cancer cases throughout the world. There are now more than 10 million
cases of cancer per year worldwide, including a group of more than 100 diseases
such as cancer of the liver, lung, stomach, colon, breast, and so forth.
The most rational way to affect carcinogenesis is by interfering with
modulation steps (initiation, promotion, and progression) as well as the
associated signal transduction pathways. There are numerous physiological and
biochemical carcinogens, for example, ultraviolet and ionizing radiation,
asbestos and tobacco smoke, infections by virus, bacteria, parasites, and
contamination of food by mycotoxins (e.g., aflatoxins causing liver cancer).
This research investigates the antineoplastic and antioxidant effects of the
ethanolic extract of Tamarindus indica bark against PANC-1 and HepG2
Cell lines. The study elucidates the underlying physiological mechanisms
contributing to anticancer and antioxidant activity, including the role of Cell
lines. Through in vitro antioxidant assays, specifically the DPPH
method, the extract demonstrated significant free radical scavenging activity,
comparable to ascorbic acid. Histological evaluations confirmed the extract's
antineoplastic properties, suggesting its potential as a natural therapeutic
agent. The findings underscore the importance of exploring plant-based treatments
for managing disease, highlighting Tamarindus Indica’s bioactive
compounds such as flavonoids and tannins as contributors to its medicinal
efficacy. This research demonstrates us about the underneath proof of
antineoplastic and antioxidant properties of Tamarindus Indica bark.
Pages:22-32
How to cite this article:
Renukaradhya M, A M Krupanidhi, Prakash Dabadi "Investigation of antineoplastic activities using Panc-1 and Hepg-2 cell lines on <i>Tamarindus indica</i> bark". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 4, 2024, Pages 22-32
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