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VOL. 9, ISSUE 4 (2024)
Evaluation of Brain Targeting Lamotrigine-Loaded Thiolated Chitosan Biodegradable Nanocomposites as Antimigraine vs. Sumatriptan
Authors
I M Higazy, H A Zaki
Abstract
Thiolated chitosan (TC) has long been perceived as a smart
temperature-responsive intranasal polymer. Mucoadhesive properties of thiolated
chitosan nanocomposites would allow its binding to nasal mucosa and act as
molecular drug-diffusion barrier. Lamotrigine (LTG) is a first-line
anti-epileptic dug that has been recommended in migraine prophylaxis, through a
number of mechanisms involving GABAergic and glutamatergic receptors, as well
as ion channels. Sumatriptan (STP) is a 5-HT agonist that has long been used as
anti-migraine, however; its vasoconstrictive effect has limited its use for
long time and for certain patients, inspite of its efficiency. In the present
study; on one hand, efficiency of thiolated chitosan nanocomposites (TCNC) is
examined through a comparative study with orally marketed tablets of both LTG
and STP. On the other hand, bioefficiency of LTG as anti-migraine is evaluated
in a comparative study with STP. Our target was achieved through
physicochemical characterization of drug loaded TCNC, in-vitro release
and ex-vivo permeation studies. Results indicated that the formula LTG2,
STP2 and F2 were the optimized, stable formulations with “drug: TC” ratio of
“1: 5”. Such formulations were then pharmacologically evaluated through in-vivo
assays involving VonFrey and Hot Plate tests. Results indicated that all
intranasal TCNC formulations were significantly effective compared to the oral
marketed tablets. LTG2 formulation proved to be the most effective compared to
all other formulations. Thus, recommending the possibility of using LTG not
only as a prophylactic drug but rather an anti-migraine.
Pages:38-45
How to cite this article:
I M Higazy, H A Zaki "Evaluation of Brain Targeting Lamotrigine-Loaded Thiolated Chitosan Biodegradable Nanocomposites as Antimigraine vs. Sumatriptan". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 4, 2024, Pages 38-45
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