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VOL. 9, ISSUE 4 (2024)
Spectrophotometric determination of PKa of Cefotoxime sodium
Authors
Mamatha Kola, N Raju, Sabavat Anjali, Mukalla Uha, Phani Vennela Mudunuri Mohammad Bakhatwar
Abstract
Acid dissociation constant is very important
parameter during drug development and to understand mechanism of drug action.
The pKa influence physiochemical properties of drug substance such as
solubility and dissolution rate. The Amount of drug that exists in unionized
form and in ionized form is a function of pKa of drug & pH of the fluid at
the absorption site. In the HPLC method development the knowledge of pka of
chemical species is very useful to choose appropriate buffer, as the retention
time of ionized and unionized form of chemical substance is different. In this
study, a simple cost-effective method to determine the pKa value of cefotaxime
sodium was proposed. The pKa value was found in good agreement with the
reported values.
Pages:53-55
How to cite this article:
Mamatha Kola, N Raju, Sabavat Anjali, Mukalla Uha, Phani Vennela Mudunuri Mohammad Bakhatwar "Spectrophotometric determination of PKa of Cefotoxime sodium". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 9, Issue 4, 2024, Pages 53-55
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