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VOL. 10, ISSUE 1 (2025)
Pemphigus vulgaris– A case report
Authors
Arshita Kumari, Tishank Sinha
Abstract
The uncommon autoimmune disease known as
Pemphigus vulgaris (PV) is typified by autoantibodies that attack desmosomal
proteins, especially desmogleins, which are essential for preserving
cell-to-cell contact in epithelial tissues. Usually, the illness is
characterized by excruciating erosions of the mucosa, which start in the mouth
and spread to the skin, where they cause bullae and vesicles. Clinical
assessment, histological analysis demonstrating acantholysis, and immunological
testing, including enzyme-linked immunosorbent assay and direct
immunofluorescence to identify anti-desmoglein antibodies, are the mainstays of
the diagnosis process. The mainstay of management is immunosuppressive
treatments, mainly systemic corticosteroids, supplemented with rituximab or
azathioprine in instances that are not responding to treatment. To maximize
patient outcomes, long-term care entails managing treatment side effects,
keeping an eye out for disease activity, and offering supportive care.
Notwithstanding advancements in treatment, PV still presents difficulties,
necessitating multidisciplinary cooperation and continuous research to enhance
patient care and quality of life.
Pages:49-50
How to cite this article:
Arshita Kumari, Tishank Sinha "Pemphigus vulgaris– A case report". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 1, 2025, Pages 49-50
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