ARCHIVES
VOL. 10, ISSUE 1 (2025)
Review on: Self micro emulsifying drug delivery system
Authors
Shradha S Bankar, Pallavi Kaple, Dr. Sonia Singh
Abstract
The self-micro emulsifying drug delivery
system (SMEDDS) is a highly effective method for improving the solubility and
bioavailability of poorly soluble drugs. The current study is exploring the
potential of this medication delivery system based on the microstructural
properties of the active ingredient and formulation. SMEDDS, an isotropic
mixture of oil, surfactant, cosurfactant, and water, encapsulates drugs into a
lipid base and forms a fine oil-in-water emulsion with gentle agitation.
Emulsification requires minimal entropy change due to peristaltic action in the
gut. Due to the microstructural characteristics of the active substance and the
formulation as a whole, using this method, extensive research is currently
being conducted to correlate the outcomes of in vitro experiments with
reactions in vivo. Given that 40% of recently discovered medications have
lipophilic properties, this suggests that research using this strategy will
continue and that more commercial formulations will soon be made accessible. A
better grasp of SMEDDS' current function in medicine and drug administration is
made possible by this review, which provides an overview of the technology with
sequential demystification.
Pages:51-58
How to cite this article:
Shradha S Bankar, Pallavi Kaple, Dr. Sonia Singh "Review on: Self micro emulsifying drug delivery system". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 1, 2025, Pages 51-58
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