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VOL. 10, ISSUE 1 (2025)
Anti-inflammatory potential of root extracts of Gmelina arborearoxb
Authors
Sandeep Goyal, Rakesh Chawla, Saveena Chauhan, Vijender Kumar
Abstract
The anti-inflammatory potential of different
root extracts of Gmelina arboreaRoxb. was investigated using the
in-vitro human red blood cell (HRBC) membrane stabilization method. Petroleum
ether extract, Chloroform, Ethyl acetate extract, methanol, and aqueous
extracts were evaluated at concentrations of 200 and 400 µg/ml, with Diclofenac
(50 and 100 µg/ml) as the standard. Among the extracts, the methanol extract
demonstrated the most significant (**p < 0.01) anti-inflammatory activity,
stabilizing the HRBC membrane effectively. These findings suggest that the
methanol extract of G. arborea may serve as a promising candidate for
developing anti-inflammatory agents. The HRBC membrane stabilization method is
an established model for assessing the efficacy of potential anti-inflammatory
agents by preventing hemolysis under hypotonic conditions. The stability
provided by plant extracts can be attributed to the inhibition of lysosomal
enzymes responsible for tissue damage and inflammation. G. arborea,
traditionally used in Ayurvedic and Unani medicine, has been reported to
possess multiple pharmacological properties, including antioxidant,
antimicrobial, and hepatoprotective activities. The significant
anti-inflammatory effects observed in the methanol extract may be due to the
presence of bioactive phytochemicals like flavonoids, lignans, and alkaloids,
which have been documented for their anti-inflammatory and membrane-stabilizing
properties. The study highlights the potential of G. arborea as an
alternative to synthetic anti-inflammatory agents, which often carry the risk
of adverse effects. Further in-vivo studies and bioactive compound isolation
are recommended to substantiate these findings and explore the underlying
mechanisms of action.
Pages:59-61
How to cite this article:
Sandeep Goyal, Rakesh Chawla, Saveena Chauhan, Vijender Kumar "Anti-inflammatory potential of root extracts of <i>Gmelina arborea</i>roxb". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 1, 2025, Pages 59-61
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