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VOL. 10, ISSUE 2 (2025)
Understanding antifungal resistance: Challenges, mechanisms, and strategies to combat rising threats
Authors
Noor Abdalwahd, Mohammed S Manji, Rafeef M abd alhussain, Baneen H Hashim
Abstract
Fungal infections have become a major global
health problem, especially among immunocompromised patients. The limited number
of antifungal drug classes and the growing resistance among fungal pathogens
makes treatment increasingly difficult. This review discusses the different
mechanisms that fungi use to resist antifungal drugs, such as target site
mutations, drug efflux, and stress responses. It also highlights clinical and
environmental factors contributing to resistance, including agricultural
practices. Finally, it explores current strategies to address antifungal
resistance, including stewardship programs, combination therapies, and the
urgent need for new antifungal drugs. A better understanding of these issues is
critical for improving outcomes and managing the growing threat of antifungal
resistance.
Pages:31-36
How to cite this article:
Noor Abdalwahd, Mohammed S Manji, Rafeef M abd alhussain, Baneen H Hashim "Understanding antifungal resistance: Challenges, mechanisms, and strategies to combat rising threats". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 2, 2025, Pages 31-36
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