ARCHIVES
VOL. 10, ISSUE 3 (2025)
Antibacterial, antifungal, antiviral, biological and immunomodulatory chemical characterization of leaves polysaccharides from Plantago palmata Hook plant
Authors
RB Singh, Ravi Prakash
Abstract
A previous work on Plantago palmataI
Hook polysaccharides (PS) attributed immunomodulatory properties of leaves to a
polysaccharide fraction (PS50) that stimulated NO and TNF-α production by
interferon gamma- (IFN-γ-) activated macrophages. The present work aims to
elucidate the chemical structure of these antibacterial, antifungal, antiviral,
biological and immunomodulatory polysaccharides. Size exclusion chromatography
showed that the active polymers present an active fraction with a very high
molecular weight (1200 kDa). These polysaccharides are pectic in nature, with a
predominantly unbranched galacturonan domain and with a domain bearing side chains
that consist of highly branched arabinan, galactan, and or arabinogalactan.
Comparatively to the well-known Plantago major biologically active PS, Plantago
palmata PS50 contained less arabinogalactan-proteins (AGPs) and had a
different composition in glucose, galactose, and galacturonic acid. DNA
contamination of the polysaccharide was estimated at about 0.04%, a
concentration much lower than those reported immunomodulatory in hyaluronic
acid preparations (3 - 15%). Therefore, the eventuality of a contaminating
DNA-mediated biological activity could be ruled out.
Pages:11-15
How to cite this article:
RB Singh, Ravi Prakash "Antibacterial, antifungal, antiviral, biological and immunomodulatory chemical characterization of leaves polysaccharides from <i>Plantago palmata </i>Hook plant". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 3, 2025, Pages 11-15
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