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VOL. 10, ISSUE 4 (2025)
Anti-hemorrhoidal activity of Cyperus rotundus underground stems
Authors
Nimbalkar Ayush, Yashraj Yadav, Jaya Sharma, Dr. PK Dubey, Raksha Goswami
Abstract
Hemorrhoids are a common anorectal disorder characterized by
inflammation, pain, and bleeding due to varicosity of rectal veins. The present
study investigates the anti-hemorrhoidal activity of hydroalcoholic and aqueous
extracts of Cyperus rotundus underground stems. Anti-inflammatory assays
(protein denaturation inhibition), rectoanal coefficient studies, and
histopathological examinations were conducted. The hydroalcoholic extract
showed significant inhibition of protein denaturation (63%) compared to the
aqueous extract (53%) and was comparable to Aspirin (76%). In vivo
studies revealed dose-dependent protection, with 400 mg/kg extract showing
activity similar to standard Pilex ointment. Histological examination confirmed
reduced mucosal damage and inflammation. The findings suggest that Cyperus
rotundus exhibits promising anti-hemorrhoidal potential, likely due to its
anti-inflammatory phytoconstituents.
Pages:1-6
How to cite this article:
Nimbalkar Ayush, Yashraj Yadav, Jaya Sharma, Dr. PK Dubey, Raksha Goswami "Anti-hemorrhoidal activity of <i>Cyperus rotundus</i> underground stems". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 4, 2025, Pages 1-6
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