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VOL. 10, ISSUE 4 (2025)
Technique for enhancing the Permeability & oral Bioavailability profile of Carbapenem
Authors
K Shanthini, Samrin Nifana A, Sandhiya U, Ushman Shalima KA, Vengat Vishal S
Abstract
Carbapenems are beta-lactam antimicrobial agent with broad
spectrum activity. Carbapenem falls under class III BCS classification based on high solubility and low permeability.
Carbapenem has a basic structure on 1, azabicyclo [3, 2, and 0]
hept-2-ene-2-carboxylic acid. In this review, we summarize the technique for
enhancing the permeability and oral bioavailability profile of carbapenem. The
techniques include Prodrug formulation, Drug as transport protein inhibitors,
Pharmaceutical excipients as transport protein inhibitors, polymeric and lipid
based nanocarriers utilized for the delivery of anti-microbial agents. This includes indications and adverse effect
of carbapenem. In closing with
marketely available and non available
formulation of Carbapenem and its derivatives.
Pages:33-36
How to cite this article:
K Shanthini, Samrin Nifana A, Sandhiya U, Ushman Shalima KA, Vengat Vishal S "Technique for enhancing the Permeability & oral Bioavailability profile of Carbapenem". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 4, 2025, Pages 33-36
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