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VOL. 10, ISSUE 4 (2025)
Exploring the IR spectral features and antimicrobial activity of 1,3,4-thiadiazole derivatives
Authors
Hridesh Singh Chauhan, Manish Thimmaraju, Jitendra Kumar Malik, Vivek Gupta, Gyan Singh
Abstract
This paper discusses the synthesis and
biological activity of 1,3,4-thiadiazole derivatives with an emphasis on their
infrared (IR) spectral properties and activity against some bacterial strains.
The IR Extremes Spectroscopy and the Antimicrobials Characterization Spectroscopy
confirmed the successful synthesis of the thiadiazole rings, as evidenced by
the –OH, C-H, and C=N stretching vibrations which correspond to the functional
substitutions as described. Antimicrobials were characterized by the diffusion
disks and Minimal Inhibitory Concentrations methods. Compound 9f stands out as
the most active, with the 23.0 mm and 22.0 mm inhibition zones against E. coli
and S. epidermidis, respectively. Compound 9d was active against S. aureus
(20.3 mm) and E. coli (21.0 mm) as well. 9f had microscopic values of 6 µg/mL
for E. coli and S. aureus, which demonstrates strong antibacterial activity.
The derivatives described here thiadiazole outlines the development of
thiadiazole derivatives as new antimicrobial candidates, especially for drug
resistant bacteria.
Pages:42-49
How to cite this article:
Hridesh Singh Chauhan, Manish Thimmaraju, Jitendra Kumar Malik, Vivek Gupta, Gyan Singh "Exploring the IR spectral features and antimicrobial activity of 1,3,4-thiadiazole derivatives". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 10, Issue 4, 2025, Pages 42-49
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